2-Cyclopropyl-4-(trifluoromethyl)benzoic acid → N-((1SR,2RS)-2-Cyclopentylamino-cyclopentyl)-2-cyclopropyl-4-trifluoromethyl-benzamide

HRID 1950993Notes

Reaction equation

HRID 1950993 reaction equation
[CH:1]1([NH:6][CH:7]2[CH2:11][CH2:10][CH2:9][CH:8]2[NH2:12])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:13]1([C:16]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:17]=2[C:18](O)=[O:19])[CH2:15][CH2:14]1>>[CH:1]1([NH:6][CH:7]2[CH2:11][CH2:10][CH2:9][CH:8]2[NH:12][C:18](=[O:19])[C:17]2[CH:21]=[CH:22][C:23]([C:25]([F:26])([F:27])[F:28])=[CH:24][C:16]=2[CH:13]2[CH2:14][CH2:15]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 594384852-Cyclopropyl-4-(trifluoromethyl)benzoic acid2×HCID 66681699HCID 66681699, compound

Product 1

HCID 51000996N-((1SR,2RS)-2-Cyclopentylamino-cyclopentyl)-2-cyclopropyl-4-trifluoromethyl-benzamide

Procedure

The title compound, brown oil, MS: m/e=381.4 [(M+H)+], was prepared in accordance with the general method of example 5 from (1RS,2SR)—N-cyclopentyl-cyclopentane-1,2-diamine (intermediate AE) and 2-cyclopropyl-4-trifluoromethyl-benzoic acid (intermediate K).

Sources & evidence

ORD record
ord-28a8b3ecd7294c24bea4a0222aabfbde
Source dataset
uspto-grants-2013_03
Patent number
US08404673B2

Reaction notes

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