cis-2-Pyrrolidin-1-yl-cyclopentylamine → 2-Isopropoxy-N-((1SR,2RS)-2-pyrrolidin-1-yl-cyclopentyl)-4-trifluoromethyl-benzamide

HRID 1950997Notes

Reaction equation

HRID 1950997 reaction equation
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:12]([O:15][C:16]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:17]=1[C:18](O)=[O:19])([CH3:14])[CH3:13]>>[CH:12]([O:15][C:16]1[CH:24]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:22]=[CH:21][C:17]=1[C:18]([NH:11][CH:7]1[CH2:8][CH2:9][CH2:10][CH:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:19])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2×HCID 59438527HCID 59438527, compound

Product 1

HCID 666814102-Isopropoxy-N-((1SR,2RS)-2-pyrrolidin-1-yl-cyclopentyl)-4-trifluoromethyl-benzamide

Procedure

The title compound, light brown oil, MS: m/e=385.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-isopropoxy-4-trifluoromethyl-benzoic acid (intermediate AF).

Sources & evidence

ORD record
ord-7920f017e82a4c368ec2d76ca20c64bb
Source dataset
uspto-grants-2013_03
Patent number
US08404673B2

Reaction notes

Loading…