N-Methylbenzylamine → HCID 25104173, compound

HRID 1951027Notes

Reaction equation

[CH2:1]([NH:8][CH3:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:10]1[O:11][N:12]=[C:13]2[CH:18]=[C:17]([C:19](Cl)=[O:20])[CH:16]=[CH:15][C:14]=12>>[CH2:1]([N:8]([CH3:9])[C:19]([C:17]1[CH:16]=[CH:15][C:14]2=[N:10][O:11][N:12]=[C:13]2[CH:18]=1)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7669N-Methylbenzylamine

HCID 27354532,1,3-Benzoxadiazole-5-carbonyl chloride

Product 1

HCID 25104173HCID 25104173, compound

Procedure

Prepared from N-benzyl-N-methylamine and [2,1,3]-benzoxadiazole-5-carbonylchloride according to the procedure previously described. N-Benzyl-N-methyl-[2,1,3]-benzoxadiazole-5-carboxamide was isolated as a white solid. Mp=105-106° C., LC-MS, MH+=268; 1H NMR (300 MHz, CDCl3, 2 rotamers) δ 7.96-7.86 (m, 1H); 7.90 (d, 1H, J=9.6 Hz); 7.43-7.30 (m, 5H); 7.19-7.13 (m, 1H); 4.78+4.56 (s+s, 2H); 3.11 and 2.94 ppm (s+s, 3H).

Sources & evidence

ORD record: ord-558aa9f6c1a34166b16d980cd41f3619
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404682B2

Reaction notes

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