Pyrrolidine → HCID 68954469, compound

HRID 1951115Notes

Reaction equation

HRID 1951115 reaction equation
N1CCC[CH2:2]1.[CH2:6]([N:13]1[CH2:17][CH:16]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[CH3:25])[CH:15]([NH2:26])[CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[CH2:6]([N:13]1[CH2:17][CH:16]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=2[CH3:25])[CH:15]([NH:26][CH3:2])[CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 67025799HCID 67025799, compound

Product 1

HCID 68954469HCID 68954469, compound

Procedure

In analogy to the procedure described for the synthesis of pyrrolidine intermediate VIII-1 (step c), the title compound [(3RS,4SR)-1-benzyl-4-(4-chloro-2-methyl-phenyl)-pyrrolidin-3-yl]-methyl-amine was prepared from (3RS,4SR)-1-benzyl-4-(4-chloro-2-methyl-phenyl)-pyrrolidin-3-ylamine instead of (3RS,4SR)-1-benzyl-4-(3,4-dichloro-phenyl)-pyrrolidin-3-ylamine and was obtained as a colorless oil. MS m/e: 315.1 [M+H]+.

Workup

  1. customwas obtained as a colorless oil

Sources & evidence

ORD record
ord-bb5627a9dac34348bc9def614fd3efa8
Source dataset
uspto-grants-2013_03
Patent number
US08404679B2

Reaction notes

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