反应详情

温度

150 °C

[5-(2-Chloro-pyridin-4-yl)-4-methyl-thiazol-2-yl]-pyrazin-2-yl-amine (Example 2b, 0.077 g, 0.254 mmol) is suspended in 3-amino-propanol (3 ml) and heated to 150° C. using microwave heating (Prolabo Synthewave™ s402 microwave oven). After 1 hour, the reaction mixture is concentrated in vacuo and diluted with water (50 ml). The aqueous is extracted with ethyl acetate (2×100 ml). The combined organic extract is dried (MgSO4) and concentrated to afford the titled compound which is purified by filtration and recrystallised from dichloromethane.

1. temperatureheating (Prolabo Synthewave™ s402 microwave oven)
2. concentrationthe reaction mixture is concentrated in vacuo
3. additiondiluted with water (50 ml)
4. extractionThe aqueous is extracted with ethyl acetate (2×100 ml)
5. extractionThe combined organic extract
6. dry with materialis dried (MgSO4)
7. concentrationconcentrated