Morpholine → HCID 67200542, compound

HRID 1951178Notes

Reaction equation

HRID 1951178 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH2:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][N:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>>[N:12]1([C:2]2[CH:7]=[C:6]([CH2:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][N:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 82653143HCID 82653143, compound

Product 1

HCID 67200542HCID 67200542, compound

Procedure

A stirred solution of 1-(2-chloro-pyridin-4-yl)-propan-2-one (1.6 g, 9.47 mmol) in morpholine is heated to 105° C. for 3 days. The morpholine is removed in vacuo to yield the crude product. Purification by chromatography on silica, eluting with 1:1 ethyl acetate-hexane affords the title compound.

Workup

  1. customThe morpholine is removed in vacuo
  2. customto yield the crude product
  3. customPurification by chromatography on silica
  4. washeluting with 1:1 ethyl acetate-hexane

Sources & evidence

ORD record
ord-5e5460eddb18410a8811bd332c810bac
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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