反应详情

A stirred solution of 1-(2-chloro-pyridin-4-yl)-propan-2-one (1.6 g, 9.47 mmol) in morpholine is heated to 105° C. for 3 days. The morpholine is removed in vacuo to yield the crude product. Purification by chromatography on silica, eluting with 1:1 ethyl acetate-hexane affords the title compound.

1. customThe morpholine is removed in vacuo
2. customto yield the crude product
3. customPurification by chromatography on silica
4. washeluting with 1:1 ethyl acetate-hexane