HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1951184Generated: October 26, 2026
1,1'-Carbonyldiimidazole → Imidazole-1-carboxylic acid (4-methyl-5-pyridin-4-yl-thiazol-2-yl)-amide
https://huagongshe.com/reaction/1951184
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2-Amino-4-methyl-5-(pyridin-4-yl)thiazole | HCID 20145003 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Imidazole-1-carboxylic acid (4-methyl-5-pyridin-4-yl-thiazol-2-yl)-amide | HCID 86610330 | — |
Reaction Steps
To a stirred solution of carbonyldiimidazole (3.91 g, 24.2 mmol) in DCM (150 ml) is added 4-methyl-5-pyridin-4-yl-thiazol-2-ylamine (prepared according to the method described in EP 117082 A2) (3.08 g, 16.1 mmol) in one portion. The suspension is stirred for 2.5 hours at 40° C. and the reaction mixture is then filtered and washed with DCM to afford the titled compound as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08404684B2 |
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| Source dataset | uspto-grants-2013_03 |
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| ORD ID | ord-944a5625b8b040939fb705f326e8475a |
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| Source note | uspto-grants-2013_03 |
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