反应详情

温度

40 °C

To a stirred solution of carbonyldiimidazole (3.91 g, 24.2 mmol) in DCM (150 ml) is added 4-methyl-5-pyridin-4-yl-thiazol-2-ylamine (prepared according to the method described in EP 117082 A2) (3.08 g, 16.1 mmol) in one portion. The suspension is stirred for 2.5 hours at 40° C. and the reaction mixture is then filtered and washed with DCM to afford the titled compound as a solid.

1. customprepared
2. filtrationthe reaction mixture is then filtered
3. washwashed with DCM