Acetylthiourea → 1-(2,6-Dimethylpyridin-4-yl)propan-2-one

HRID 1951186Notes

Reaction equation

HRID 1951186 reaction equation
CC1N=C(NC2C=NC=CN=2)SC=1C1C=CN=CC=1.[CH3:20][C:21]1[CH:26]=[C:25]([CH2:27][C:28](=[O:30])[CH3:29])[CH:24]=[C:23]([CH3:31])[N:22]=1.N1C=CN=CC=1NC(N)=S.[C:42]([NH:45][C:46]([NH2:48])=[S:47])(=[O:44])[CH3:43]>>[CH3:20][C:21]1[CH:26]=[C:25]([C:27]2[S:47][C:46]([NH:45][C:42](=[O:44])[CH3:43])=[N:48][C:28]=2[CH3:29])[CH:24]=[C:23]([CH3:31])[N:22]=1.[CH3:20][C:21]1[CH:26]=[C:25]([CH2:27][C:28](=[O:30])[CH3:29])[CH:24]=[C:23]([CH3:31])[N:22]=1

Participants

6

Reactant 4

HCID 2723593AcetylthioureaHCID 2771013N-PyrazinylthioureaHCID 11254215HCID 11254215, compoundHCID 125218221-(2,6-Dimethylpyridin-4-yl)propan-2-one

Product 2

HCID 125218221-(2,6-Dimethylpyridin-4-yl)propan-2-oneHCID 86610331HCID 86610331, compound

Procedure

The titled compound is prepared by an analogous procedure to (4-Methyl-5-pyridin-4-yl-thiazol-2-yl)-pyrazin-2-yl-amine (Example 1) by replacing 1-pyridin-4-yl-propan-2-one (1b) in this procedure with 1-(2,6-dimethyl-pyridin-4-yl)-propan-2-one and by replacing and pyrazin-2-yl-thiourea (1a) with N-acetylthiourea. 1-(2,6-dimethyl-pyridin-4-yl)-propan-2-one was prepared according to a method described in Tetrahedron Letters, Vol. 25, No. 5, pp 515-518, 1984. (Authors: Claude Erre et al.)

Sources & evidence

ORD record
ord-1118582b94ed499eb8952dd9ab18e9c6
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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