Bromine → HCID 86653055, compound

HRID 1951200Notes

Reaction equation

HRID 1951200 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[C:8]([CH2:10][C:11](=[O:13])[CH3:12])[CH:7]=[CH:6][N:5]=1>O1CCOCC1>[Br:1][CH:10]([C:8]1[CH:7]=[CH:6][N:5]=[C:4]([Cl:3])[CH:9]=1)[C:11](=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 82653143HCID 82653143, compound

Product 1

HCID 86653055HCID 86653055, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Bromine (1.36 ml, 26 mmol) is added dropwise to a stirred solution of 1-(2-chloro-pyridin-4-yl)-propan-2-one (Example 2a, 5.0 g, 29.5 mmol) in dioxane (150 ml) over 45 minutes at 5-10° C. After 20 minutes at room temperature the solvent is removed in vacuo to afford the titled compound as a yellow solid.

Workup

  1. customAfter 20 minutes at room temperature the solvent is removed in vacuo

Sources & evidence

ORD record
ord-9fca1a9703ec44b0be613960b1bfb8f7
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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