Bromine → HCID 86653058, compound

HRID 1951210Notes

Reaction equation

HRID 1951210 reaction equation
[Br:1]Br.[C:3]([C:7]1[N:12]=[C:11]([CH2:13][C:14](=[O:16])[CH3:15])[CH:10]=[CH:9][N:8]=1)([CH3:6])([CH3:5])[CH3:4]>C(Cl)(Cl)Cl.O1CCOCC1>[Br:1][CH:13]([C:11]1[CH:10]=[CH:9][N:8]=[C:7]([C:3]([CH3:6])([CH3:4])[CH3:5])[N:12]=1)[C:14](=[O:16])[CH3:15]

Participants

5

Reactant 2

HCID 24408BromineHCID 67200560HCID 67200560, compound

Product 1

HCID 86653058HCID 86653058, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
12.5 °C

Procedure

Bromine (3.25 g, 20.7 mmol) in chloroform (20 ml) is added dropwise over 5 hours to a stirred solution of 1-(2-tert-butyl-pyrimidin-4-yl)-propan-2-one (4.0 g, 20.7 mmol) in dioxane (300 ml) maintained at 10-15° C. When the addition is complete the solvent is removed in vacuo to give the titled compound as a hydrobromide salt.

Workup

  1. additionWhen the addition
  2. customis removed in vacuo

Sources & evidence

ORD record
ord-d96a40a0bc444a7b8bc40fdea427868f
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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