Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | HCID 67200560 | HCID 67200560 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86653058 | HCID 86653058 | — |
Reaction Steps
Bromine (3.25 g, 20.7 mmol) in chloroform (20 ml) is added dropwise over 5 hours to a stirred solution of 1-(2-tert-butyl-pyrimidin-4-yl)-propan-2-one (4.0 g, 20.7 mmol) in dioxane (300 ml) maintained at 10-15° C. When the addition is complete the solvent is removed in vacuo to give the titled compound as a hydrobromide salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08404684B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-d96a40a0bc444a7b8bc40fdea427868f |
|---|
| Source note | uspto-grants-2013_03 |
|---|
