Thiourea → HCID 11425177, compound

HRID 1951211Notes

Reaction equation

HRID 1951211 reaction equation
Br[CH:2]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12]([CH3:15])([CH3:14])[CH3:13])[N:7]=1)[C:3](=O)[CH3:4].[NH2:16][C:17]([NH2:19])=[S:18]>C(O)C>[C:12]([C:8]1[N:7]=[C:6]([C:2]2[S:18][C:17]([NH2:19])=[N:16][C:3]=2[CH3:4])[CH:11]=[CH:10][N:9]=1)([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 86653058HCID 86653058, compound

Product 1

HCID 11425177HCID 11425177, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Bromo-1-(2-tert-butyl-pyrimidin-4-yl)-propan-2-one (1 g, 37 mmol) is stirred in ethanol (40 ml) at 70° C. Thiourea (280 mg, 37 mmol) is added and stirring continued for 1 hour at 70° C. After cooling to room temperature the mixture is filtered to afford the titled compound as the hydrobromide salt. If required, the product is dissolved in 1M aqueous hydrochloric acid and the solution is brought to pH 8 by addition of sodium hydroxide solution to precipitate the titled compound as the free base.

Workup

  1. filtrationis filtered

Sources & evidence

ORD record
ord-01e21225a9ca42fd9303064f215720bd
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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