Thiourea → HCID 11425177, compound

Participants

Reaction Steps

1-Bromo-1-(2-tert-butyl-pyrimidin-4-yl)-propan-2-one (1 g, 37 mmol) is stirred in ethanol (40 ml) at 70° C. Thiourea (280 mg, 37 mmol) is added and stirring continued for 1 hour at 70° C. After cooling to room temperature the mixture is filtered to afford the titled compound as the hydrobromide salt. If required, the product is dissolved in 1M aqueous hydrochloric acid and the solution is brought to pH 8 by addition of sodium hydroxide solution to precipitate the titled compound as the free base.

Provenance & Evidence