反应详情

温度

90 °C

Hydrazine hydrate (0.27 ml, 6.69 mmol) is added to a stirred solution of [3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pyrazol-1-yl]-acetic acid tert-butyl ester (2.18 g, 6.69 mmol) in ethanol (12 ml). The reaction is stirred at 90° C. for 2.5 hours. When cool, the reaction is diluted with ethanol (50 ml) and the white precipitate is removed by filtration, washing with more ethanol (250 ml). The combined filtrate is evaporated to dryness and dichloromethane (100 ml) is added. After filtering again, the filtrate is evaporated to give the titled compound as a colourless oil.

1. temperatureWhen cool
2. customthe white precipitate is removed by filtration
3. washwashing with more ethanol (250 ml)
4. customThe combined filtrate is evaporated to dryness and dichloromethane (100 ml)
5. additionis added
6. filtrationAfter filtering again
7. customthe filtrate is evaporated