HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester | HCID 86653060 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 3-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid | HCID 86606221 | — |
Reaction Steps
Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester (0.675 g, 2.91 mmol) is suspended in 2M NaOH (8 ml) and the reaction is stirred at reflux for 3.5 hours. When cool, the solution is acidified to pH 3 with 6M HCl and the titled compound is removed by filtration and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404684B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-e963e179c2b34315ad0c3f3def9be1e2 |
| Source note | uspto-grants-2013_03 |