Hydrochloric Acid → 3-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid

HRID 1951225Notes

Reaction equation

HRID 1951225 reaction equation
C[O:2][C:3](=[O:20])[CH:4](C(OCC)=O)[CH2:5][C:6]1[S:7][C:8]([NH:11][C:12]([NH2:14])=[S:13])=[N:9][N:10]=1.Cl>[OH-].[Na+]>[NH:11]([C:8]1[S:7][C:6]([CH2:5][CH2:4][C:3]([OH:20])=[O:2])=[N:10][N:9]=1)[C:12]([NH2:14])=[S:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86653060Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester

Product 1

HCID 866062213-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester (0.675 g, 2.91 mmol) is suspended in 2M NaOH (8 ml) and the reaction is stirred at reflux for 3.5 hours. When cool, the solution is acidified to pH 3 with 6M HCl and the titled compound is removed by filtration and dried.

Workup

  1. temperatureat reflux for 3.5 hours
  2. temperatureWhen cool
  3. customthe titled compound is removed by filtration
  4. customdried

Sources & evidence

ORD record
ord-e963e179c2b34315ad0c3f3def9be1e2
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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