反应详情

Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester (0.675 g, 2.91 mmol) is suspended in 2M NaOH (8 ml) and the reaction is stirred at reflux for 3.5 hours. When cool, the solution is acidified to pH 3 with 6M HCl and the titled compound is removed by filtration and dried.

1. temperatureat reflux for 3.5 hours
2. temperatureWhen cool
3. customthe titled compound is removed by filtration
4. customdried