m-Chloroperbenzoic acid → HCID 11281950, compound

HRID 1951229Notes

Reaction equation

HRID 1951229 reaction equation
[CH2:1]([C:3]1[O:7][C:6]([CH2:8][CH2:9][NH:10][C:11]([NH:13][C:14]2[S:15][C:16]([C:20]3[CH:25]=[C:24]([CH3:26])[N:23]=[C:22]([S:27][CH3:28])[N:21]=3)=[C:17]([CH3:19])[N:18]=2)=[O:12])=[N:5][CH:4]=1)[CH3:2].ClC1C=C(C=CC=1)C(OO)=[O:34].CS(C1N=C(C2SC(N)=NC=2C)C=C(C)N=1)=O>>[CH2:1]([C:3]1[O:7][C:6]([CH2:8][CH2:9][NH:10][C:11]([NH:13][C:14]2[S:15][C:16]([C:20]3[CH:25]=[C:24]([CH3:26])[N:23]=[C:22]([S:27]([CH3:28])=[O:34])[N:21]=3)=[C:17]([CH3:19])[N:18]=2)=[O:12])=[N:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 3

HCID 70297m-Chloroperbenzoic acidHCID 11189294HCID 11189294, compoundHCID 86610340HCID 86610340, compound

Product 1

HCID 11281950HCID 11281950, compound

Procedure

This compound is prepared by oxidation of 1-[2-(5-ethyl-oxazol-2-yl)-ethyl]-3-[4-methyl-5-(6-methyl-2-methylsulfanyl-pyrimidin-4-yl)-thiazol-2-yl]-urea with m-CPBA (meta-chloroperoxy-benzoic acid) following the protocol used to prepare 5-(2-Methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-ylamine (intermediate AD).

Sources & evidence

ORD record
ord-c97ea25fc0794cbb9ee88ac3e0276ff4
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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