Dimethylamine → HCID 11407355, compound

HRID 1951231Notes

Reaction equation

HRID 1951231 reaction equation
[CH2:1]([C:3]1[O:7][C:6]([CH2:8][CH2:9][NH:10][C:11]([NH:13][C:14]2[S:15][C:16]([C:20]3[CH:25]=[C:24]([CH3:26])[N:23]=[C:22](S(C)(=O)=O)[N:21]=3)=[C:17]([CH3:19])[N:18]=2)=[O:12])=[N:5][CH:4]=1)[CH3:2].[CH3:31][NH:32][CH3:33]>CN(C=O)C>[CH3:31][N:32]([CH3:33])[C:22]1[N:21]=[C:20]([C:16]2[S:15][C:14]([NH:13][C:11]([NH:10][CH2:9][CH2:8][C:6]3[O:7][C:3]([CH2:1][CH3:2])=[CH:4][N:5]=3)=[O:12])=[N:18][C:17]=2[CH3:19])[CH:25]=[C:24]([CH3:26])[N:23]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 11259470HCID 11259470, compound

Product 1

HCID 11407355HCID 11407355, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-[2-(5-ethyl-oxazol-2-yl)-ethyl]-3-[5-(2-methanesulfonyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea (0.22 g, 0.049 mmol) and dimethylamine (2M in THF, 0.073 ml, 0.15 mmol) in DMF (1 ml) is heated at 70° C. for 18 hours. The solvent is removed and the product is purified by chromatography on silica eluting with ethyl acetate to give the titled compound.

Workup

  1. customThe solvent is removed
  2. customthe product is purified by chromatography on silica eluting with ethyl acetate

Sources & evidence

ORD record
ord-b1076c4795534988a6fc969d2c76de61
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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