1,2-Ethanediamine, N1,N1,N2-trimethyl- → 1-(5-[2-[(2-Dimethylamino-ethyl)-methyl-amino]-6-methyl-pyrimidin-4-yl]-4-methyl-thiazol-2-yl)-3-[2-(1-ethyl-1H-imidazol-4-yl)-ethyl]-urea

HRID 1951236Notes

Reaction equation

HRID 1951236 reaction equation
[CH2:1]([N:3]1[CH:7]=[C:6]([CH2:8][CH2:9][NH:10][C:11]([NH:13][C:14]2[S:15][C:16]([C:20]3[CH:25]=[C:24]([CH3:26])[N:23]=[C:22](S(C)=O)[N:21]=3)=[C:17]([CH3:19])[N:18]=2)=[O:12])[N:5]=[CH:4]1)[CH3:2].[CH3:30][N:31]([CH3:36])[CH2:32][CH2:33][NH:34][CH3:35]>O1CCOCC1>[CH3:30][N:31]([CH3:36])[CH2:32][CH2:33][N:34]([CH3:35])[C:22]1[N:21]=[C:20]([C:16]2[S:15][C:14]([NH:13][C:11]([NH:10][CH2:9][CH2:8][C:6]3[N:5]=[CH:4][N:3]([CH2:1][CH3:2])[CH:7]=3)=[O:12])=[N:18][C:17]=2[CH3:19])[CH:25]=[C:24]([CH3:26])[N:23]=1

Participants

4

Reactant 2

HCID 673381,2-Ethanediamine, N1,N1,N2-trimethyl-HCID 111663941-[2-(1-Ethyl-1H-imidazol-4-yl)-ethyl]-3-[5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea

Product 1

HCID 866530621-(5-[2-[(2-Dimethylamino-ethyl)-methyl-amino]-6-methyl-pyrimidin-4-yl]-4-methyl-thiazol-2-yl)-3-[2-(1-ethyl-1H-imidazol-4-yl)-ethyl]-urea

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

This material is prepared from 1-[2-(1-ethyl-1H-imidazol-4-yl)-ethyl]-3-[5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea and N,N,N′-trimethyl-ethane-1,2-diamine using the protocol described for Example 42 but replacing DMF by dioxane.

Sources & evidence

ORD record
ord-055d1a04be6c49cca1cb09c33f0c8517
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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