HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Ethanediamine, N1,N1,N2-trimethyl- → 1-(5-[2-[(2-Dimethylamino-ethyl)-methyl-amino]-6-methyl-pyrimidin-4-yl]-4-methyl-thiazol-2-yl)-3-[2-(1-ethyl-1H-imidazol-4-yl)-ethyl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Ethanediamine, N1,N1,N2-trimethyl- | HCID 67338 | — |
| Reactant | 1-[2-(1-Ethyl-1H-imidazol-4-yl)-ethyl]-3-[5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea | HCID 11166394 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(5-[2-[(2-Dimethylamino-ethyl)-methyl-amino]-6-methyl-pyrimidin-4-yl]-4-methyl-thiazol-2-yl)-3-[2-(1-ethyl-1H-imidazol-4-yl)-ethyl]-urea | HCID 86653062 | — |
Reaction Steps
This material is prepared from 1-[2-(1-ethyl-1H-imidazol-4-yl)-ethyl]-3-[5-(2-methanesulfinyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea and N,N,N′-trimethyl-ethane-1,2-diamine using the protocol described for Example 42 but replacing DMF by dioxane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404684B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-055d1a04be6c49cca1cb09c33f0c8517 |
| Source note | uspto-grants-2013_03 |