Sodium Cyanide → HCID 11395772, compound

HRID 1951238Notes

Reaction equation

HRID 1951238 reaction equation
[C-:1]#[N:2].[Na+].[CH:4]([N:7]1[CH:11]=[C:10]([CH2:12][CH2:13][NH:14][C:15]([NH:17][C:18]2[S:19][C:20]([C:24]3[CH:29]=[C:28]([CH3:30])[N:27]=[C:26](S(C)(=O)=O)[N:25]=3)=[C:21]([CH3:23])[N:22]=2)=[O:16])[N:9]=[CH:8]1)([CH3:6])[CH3:5]>CS(C)=O>[C:1]([C:26]1[N:25]=[C:24]([C:20]2[S:19][C:18]([NH:17][C:15]([NH:14][CH2:13][CH2:12][C:10]3[N:9]=[CH:8][N:7]([CH:4]([CH3:6])[CH3:5])[CH:11]=3)=[O:16])=[N:22][C:21]=2[CH3:23])[CH:29]=[C:28]([CH3:30])[N:27]=1)#[N:2]

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 86610345HCID 86610345, compound

Product 1

HCID 11395772HCID 11395772, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
50 °C

Procedure

Sodium cyanide (0.069 g, 1.4 mmol) is added to a stirred solution of 1-[2-(1-isopropyl-1H-imidazol-4-yl)-ethyl]-3-[5-(2-methanesulfonyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-urea (0.21 g, 0.47 mmol) in dry DMSO (10 ml). The reaction is stirred at 50° C. under argon for 3 hours then the solvent is removed. The residue is dissolved in DCM and washed with water. The organic extract is dried (MgSO4) and the solvent removed to give the titled compound.

Workup

  1. customthe solvent is removed
  2. dissolutionThe residue is dissolved in DCM
  3. washwashed with water
  4. extractionThe organic extract
  5. dry with materialis dried (MgSO4)
  6. customthe solvent removed

Sources & evidence

ORD record
ord-c54ebb94f4ab4b7e83e18d77d23c12e8
Source dataset
uspto-grants-2013_03
Patent number
US08404684B2

Reaction notes

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