5-Bromothiophene-2-carboxylic acid → 5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide

HRID 1951254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1951254
[Br:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.Cl.[NH2:11][C:12]1[CH:13]=[C:14]([CH:21]=[CH:22][C:23]=1[CH3:24])[C:15]([NH:17][CH:18]1[CH2:20][CH2:19]1)=[O:16]>>[Br:1][C:2]1[S:6][C:5]([C:7]([NH:11][C:12]2[CH:13]=[C:14]([C:15](=[O:16])[NH:17][CH:18]3[CH2:20][CH2:19]3)[CH:21]=[CH:22][C:23]=2[CH3:24])=[O:9])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 3491155-Bromothiophene-2-carboxylic acidHCID 442031943-Amino-N-cyclopropyl-4-methylbenzamide hydrochloride

Produkt 1

HCID 597614015-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide

Versuchsvorschrift

Compound a was prepared by coupling 5-bromothiophene-2-carboxylic acid with 3-amino-N-cyclopropyl-4-methylbenzamide hydrochloride (prepared as described in WO04071440) using the method described in Example 2. HPLC Ret time=3.16 min. LCMS [M+H]+ 379.15.

Aufarbeitung

  1. customCompound a was prepared
  2. customHPLC Ret time=3.16 min

Quellen und Nachweise

ORD-Eintrag
ord-522a2bc5e4bc48dc9fd40d6a644bf4d5
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08404689B2

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