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5-Bromothiophene-2-carboxylic acid → 5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Bromothiophene-2-carboxylic acid | HCID 349115 | — |
| 反応物 | 3-Amino-N-cyclopropyl-4-methylbenzamide hydrochloride | HCID 44203194 | — |
| 生成物 | 5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide | HCID 59761401 | — |
反応手順
Compound a was prepared by coupling 5-bromothiophene-2-carboxylic acid with 3-amino-N-cyclopropyl-4-methylbenzamide hydrochloride (prepared as described in WO04071440) using the method described in Example 2. HPLC Ret time=3.16 min. LCMS [M+H]+ 379.15.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08404689B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-522a2bc5e4bc48dc9fd40d6a644bf4d5 |
| 出典メモ | uspto-grants-2013_03 |