Water → Pyrrolo[1,2-b]pyridazin-4(1H)-one

HRID 1951287Notes

Reaction equation

HRID 1951287 reaction equation
[O:1]=[C:2]1[C:7](C(OCC)=O)=[CH:6][NH:5][N:4]2[CH:13]=[CH:14][CH:15]=[C:3]12.[Cl-].[Na+].O>CS(C)=O>[NH:5]1[CH:6]=[CH:7][C:2](=[O:1])[C:3]2=[CH:15][CH:14]=[CH:13][N:4]12

Participants

5

Reactant 3

HCID 962WaterHCID 5234Sodium ChlorideHCID 10104421ETHYL 4-OXO-1,4-DIHYDROPYRROLO[1,2-B]PYRIDAZINE-3-CARBOXYLATE

Product 1

HCID 57415871Pyrrolo[1,2-b]pyridazin-4(1H)-one

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Ethyl 4-oxo-1,4-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate (412 mg, 2.00 mmol), sodium chloride (200 mg), water (1 mL), and DMSO (1 mL) were heated at 150° C. for 3 hours. The solvent was concentrated in vacuo and the residue was purified using 0-50% EtOAc/Hexanes to provide pyrrolo[1,2-b]pyridazin-4(1H)-one. MS: Found M+H+=135.

Workup

  1. concentrationThe solvent was concentrated in vacuo
  2. customthe residue was purified

Sources & evidence

ORD record
ord-fefc6a9c646343caa1da97acd46952d1
Source dataset
uspto-grants-2013_03
Patent number
US08404694B2

Reaction notes

Loading…