HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Pyrrolo[1,2-b]pyridazin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | ETHYL 4-OXO-1,4-DIHYDROPYRROLO[1,2-B]PYRIDAZINE-3-CARBOXYLATE | HCID 10104421 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Pyrrolo[1,2-b]pyridazin-4(1H)-one | HCID 57415871 | — |
Reaction Steps
Ethyl 4-oxo-1,4-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate (412 mg, 2.00 mmol), sodium chloride (200 mg), water (1 mL), and DMSO (1 mL) were heated at 150° C. for 3 hours. The solvent was concentrated in vacuo and the residue was purified using 0-50% EtOAc/Hexanes to provide pyrrolo[1,2-b]pyridazin-4(1H)-one. MS: Found M+H+=135.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404694B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-fefc6a9c646343caa1da97acd46952d1 |
| Source note | uspto-grants-2013_03 |