HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Bromide → (2-(Trifluoromethyl)imidazo[1,2-a]pyridin-8-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Bromide | HCID 253877 | — |
| Reactant | Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester | HCID 46205405 | — |
| Product | (2-(Trifluoromethyl)imidazo[1,2-a]pyridin-8-yl)methanol | HCID 46205729 | — |
Reaction Steps
From 2e (yield: 54%); mp 118-120° C.; IR (KBr) 3400-3100, 1225, 1163 cm−1; 1H NMR (400 MHz, CDCl3) δ 5.06 (s, 2H), 6.95 (t, 1H, J=7 Hz), 7.31 (d, 1H, J=7 Hz), 7.92 (s, 1H), 8.11 (d, 1H, J=7 Hz); 13C NMR (100 MHz, CDCl3) δ 61.7, 111.9, 114.0, 121.5 (d, 1JF-C=267 Hz), 123.3, 125.2, 131.0, 135.4 (q, 2JF-C=39 Hz), 144.4; MS m/z 216 (M+, 50), 215 (100), 195 (25), 187 (20), 167 (29).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404707B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-5816c794e3b2495e8d31d39beb387023 |
| Source note | uspto-grants-2013_03 |