Potassium Bromide → HCID 46205729, compound

HRID 1951323Notes

Reaction equation

HRID 1951323 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[N:4]=[C:5]2[C:10]([C:11](OCC)=[O:12])=[CH:9][CH:8]=[CH:7][N:6]2[CH:16]=1.[K+].[Br-]>>[OH:12][CH2:11][C:10]1[C:5]2[N:6]([CH:16]=[C:3]([C:2]([F:18])([F:17])[F:1])[N:4]=2)[CH:7]=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 253877Potassium BromideHCID 46205405Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester

Product 1

HCID 46205729HCID 46205729, compound

Procedure

From 2e (yield: 54%); mp 118-120° C.; IR (KBr) 3400-3100, 1225, 1163 cm−1; 1H NMR (400 MHz, CDCl3) δ 5.06 (s, 2H), 6.95 (t, 1H, J=7 Hz), 7.31 (d, 1H, J=7 Hz), 7.92 (s, 1H), 8.11 (d, 1H, J=7 Hz); 13C NMR (100 MHz, CDCl3) δ 61.7, 111.9, 114.0, 121.5 (d, 1JF-C=267 Hz), 123.3, 125.2, 131.0, 135.4 (q, 2JF-C=39 Hz), 144.4; MS m/z 216 (M+, 50), 215 (100), 195 (25), 187 (20), 167 (29).

Sources & evidence

ORD record
ord-5816c794e3b2495e8d31d39beb387023
Source dataset
uspto-grants-2013_03
Patent number
US08404707B2

Reaction notes

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