Potassium Bromide → HCID 46206054, compound

HRID 1951331Notes

Reaction equation

[OH:1][CH2:2][C:3]1[C:4]2[N:5]([CH:9]=[C:10]([C:12]([F:15])([F:14])[F:13])[N:11]=2)[CH:6]=[CH:7][CH:8]=1.[K+].[Br-]>>[F:15][C:12]([F:13])([F:14])[C:10]1[N:11]=[C:4]2[C:3]([CH:2]=[O:1])=[CH:8][CH:7]=[CH:6][N:5]2[CH:9]=1

Participants

Reactant 2

HCID 253877Potassium Bromide

HCID 46205729HCID 46205729, compound

Product 1

HCID 46206054HCID 46206054, compoundYield 96%

Procedure

From 3e: reaction time 6 h (yield: 96%); mp 98-100° C.; IR (KBr) 1709, 1164 cm−1; 1H NMR (200 MHz, CDCl3) δ 7.12 (t, 1H, J=7 Hz), 7.94 (d, 1H, J=7 Hz), 8.06 (s, 1H), 8.46 (d, 1H, J=7 Hz), 10.73 (s, 1H); 13C NMR (100 MHz, CDCl3) δ 112.3, 113.6, 118.6 (d, 1JF-C=267 Hz), 122.6, 124.8, 128.0, 131.1, 137.0 (q, 2JF-C=30 Hz), 144.2, 188.0; MS m/z 214 (M+, 39), 186 (100), 166 (52), 139 (25), 92 (22), 75 (55), 64 (26).

Sources & evidence

ORD record: ord-7790eb3d8fb1440cabb72578cc6308c6
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404707B2

Reaction notes

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