反应详情

21 g (130 mmol) of 4-formyl-3-methoxybenzonitrile, 14.7 ml (143 mmol) of 2,4-pentanedione, 11.2 ml (195 mmol) of acetic acid and 2.6 ml (26 mmol) of piperidine in 400 ml of dry dichloromethane are stirred under reflux with a water trap for 24 h. After cooling, the reaction solution is washed successively with saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic phase is dried over magnesium sulfate and concentrated. The residue is recrystallized from diethyl ether. 23.2 g (92% of theory) of the title compound are obtained as a pale brown solid.

1. temperatureunder reflux with a water trap for 24 h
2. temperatureAfter cooling
3. washthe reaction solution is washed successively with saturated sodium bicarbonate solution and saturated sodium chloride solution
4. dry with materialThe organic phase is dried over magnesium sulfate
5. concentrationconcentrated
6. customThe residue is recrystallized from diethyl ether