反应详情

181 mg (0.97 mmol) of the compound from example 11A, 150 mg (0.97 mmol) of the compound from example 4A and 79 mg (0.97 mmol) of 3-aminocrotononitrile are dissolved in 4 ml of isopropanol and stirred at the reflux temperature overnight. After cooling to room temperature, the volatile components are removed in a rotary evaporator, the crude material is taken up in 5 ml of ethyl acetate, and the precipitated product is then filtered off 240 mg (64% of theory) of the title compound are obtained.

1. customthe volatile components are removed in a rotary evaporator
2. filtrationthe precipitated product is then filtered off 240 mg (64% of theory) of the title compound
3. customare obtained