反应详情

温度

55 °C

To a solution of the crude product of Step 3 (4 g) in 50 ml of 1:1 MeOH/THF was added 25 ml of 1N aqueous LiOH solution. The reaction mixture was stirred at 55° C. for 4 h and the concentrated under reduced pressure to move the volatile solvent. The resulting aqueous solution was treated with 5 ml of AcOH and stirred for 2 h. The solid was collected by filtration to give 3.2 of the title compound as a white powder.

1. concentrationthe concentrated under reduced pressure
2. additionThe resulting aqueous solution was treated with 5 ml of AcOH
3. stirringstirred for 2 h
4. filtrationThe solid was collected by filtration