Water → HCID 68691349, compound

HRID 1951755Notes

Reaction equation

HRID 1951755 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[CH2:12]([CH2:19][NH2:20])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[NH:21]1[CH:25]=[CH:24][N:23]=[N:22]1.O.[C:27]1(C)C=CC=CC=1>>[CH2:12]([CH2:19][NH:20][C:8]1([N:23]2[CH:27]=[CH:24][CH2:25][N:21]=[N:22]2)[CH2:9][CH2:10][C:5]2([O:4][CH2:3][CH2:2][O:1]2)[CH2:6][CH2:7]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

6

Reactant 5

HCID 962WaterHCID 1001PhenethylamineHCID 1140TolueneHCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 178418936HCID 178418936, compound

Product 1

HCID 68691349HCID 68691349, compound

Procedure

A solution of 1,4-dioxaspiro[4,5]decan-8-one (3.9 g, 25 mmol), N-benzylmethylamine (3.32 g, 3.54 ml, 27.5 mmol) and 1,2,3-triazole (2.07 g, 30 mmol) in toluene (40 ml) was heated for 8 h under reflux in a water separator (Dean-Stark). After cooling to room temperature, the reaction solution was directly used further.

Sources & evidence

ORD record
ord-bdb456fbd33848a2b7ac228debbee7f3
Source dataset
uspto-grants-2013_03
Patent number
US08404740B2

Reaction notes

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