Benzylamine → HCID 11043015, compound

HRID 1951757Notes

Reaction equation

HRID 1951757 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:9]1[C:13]2([CH2:18][CH2:17][C:16](=O)[CH2:15][CH2:14]2)[O:12][CH2:11][CH2:10]1>ClCCl>[CH2:1]([N:8]=[C:16]1[CH2:17][CH2:18][C:13]2([O:12][CH2:11][CH2:10][O:9]2)[CH2:14][CH2:15]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 11043015HCID 11043015, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4 Å molecular sieve (20 g) and benzylamine (8.90 g, 83 mmol) were added to a solution of 1,4-dioxaspiro[4.5]decan-8-one (10.0 g, 64 mmol) in dichloromethane (100 ml), and the reaction mixture was stirred for 16 h at room temperature. The suspension was then filtered and the filtrate was concentrated in vacuo.

Workup

  1. filtrationThe suspension was then filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-3a777d842b784d59af2e092b7878a14b
Source dataset
uspto-grants-2013_03
Patent number
US08404740B2

Reaction notes

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