Methyl bromoacetate → HCID 68583797, compound

HRID 1951876Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([CH2:23][C:24]2[CH:33]=[CH:32][C:31]3[C:26](=[CH:27][CH:28]=[C:29]([O:34][CH3:35])[CH:30]=3)[CH:25]=2)[N:12]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)[CH:13]=1.Br[CH2:37][C:38]([O:40][CH3:41])=[O:39]>>[CH3:41][O:40][C:38](=[O:39])[CH2:37][NH:20][C:17]1[CH:18]=[CH:19][C:14]([N:12]2[CH:13]=[C:9]([C:3]3[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])[N:10]=[C:11]2[CH2:23][C:24]2[CH:33]=[CH:32][C:31]3[C:26](=[CH:27][CH:28]=[C:29]([O:34][CH3:35])[CH:30]=3)[CH:25]=2)=[CH:15][CH:16]=1

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 68582533HCID 68582533, compound

Product 1

HCID 68583797HCID 68583797, compound

Procedure

4-(2,4-Dichloro-phenyl)-1-(4-nitro-phenyl)-2-(6-methoxy-naphthalen-2-ylmethyl)-1H-imidazole (252 mg, 0.5 mmol) was reduced to amine and was reacted with methyl bromoacetate following general procedures D & E to give {4-[4-(2,4-dichloro-phenyl)-2-(6-methoxy-naphthalen-2-ylmethyl)-imidazol-1-yl]-phenylamino}-acetic acid methyl ester.

Sources & evidence

ORD record: ord-79c92ee09be5474fbe10889dc7e4f1b4
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404731B2

Reaction notes

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