1,4-Dioxane hydrochloride → HCID 67426079, compound

HRID 1951913Notes

Reaction equation

HRID 1951913 reaction equation
[ClH:1].O1CCOCC1.[CH2:8]([C@H:12]1[N:19](C(OC(C)(C)C)=O)[CH2:18][C:15]2([CH2:17][CH2:16]2)[N:14]([C:27]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:28])[CH2:13]1)[CH:9]([CH3:11])[CH3:10]>O1CCOCC1>[ClH:1].[CH2:8]([C@H:12]1[NH:19][CH2:18][C:15]2([CH2:16][CH2:17]2)[N:14]([C:27]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:28])[CH2:13]1)[CH:9]([CH3:11])[CH3:10]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 58542327HCID 58542327, compound

Product 1

HCID 67426079HCID 67426079, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4 N hydrochloric acid/dioxane (8 ml) was added to a dioxane (10 ml) solution of the compound (0.57 g, 1.42 mmol) obtained in Step 4 above under ice cooling and the resulting mixture was gradually returned to room temperature while being stirred for 24 hours. The reaction mixture was concentrated under reduced pressure to give the title compound as a colorless solid.

Workup

  1. customwas gradually returned to room temperature
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-bba27379368645509255fd0004d6c7c0
Source dataset
uspto-grants-2013_03
Patent number
US08404691B2

Reaction notes

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