反应详情

The compound (16.00 g, 57.07 mmol) obtained in Step 2 was dissolved in 1,4-dioxane. Selenium dioxide (63.33 g, 570.07 mmol) was added thereto and refluxed for 10 hrs, followed by cooling. The resulting mixture washed with 1M sodium bicarbonate, and successively extracted with diethyl ether. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 10.198 g of the titled compound (yield: 61%) as a red solid.

1. temperaturerefluxed for 10 hrs
2. temperatureby cooling
3. washThe resulting mixture washed with 1M sodium bicarbonate
4. extractionsuccessively extracted with diethyl ether
5. customThe organic layer was separated
6. dry with materialdried over anhydrous MgSO4
7. concentrationconcentrated under a reduced pressure
8. customThe resulting residue was purified by flash chromatography