反应详情

6-Methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (1 g, 3.39 mmol) prepared in Preparation Example 1 was dissolved in 1,4-dioxane and selenium dioxide (5.65 g, 50.96 mmol) was added thereto. The mixture was refluxed for 24 hrs, cooled, washed with 1M sodium bicarbonate, and extracted with diethyl ether. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 756 mg of the titled compound (yield: 72%) as a red solid.

1. temperatureThe mixture was refluxed for 24 hrs
2. temperaturecooled
3. washwashed with 1M sodium bicarbonate
4. extractionextracted with diethyl ether
5. customThe organic layer was separated
6. dry with materialdried over anhydrous MgSO4
7. concentrationconcentrated under a reduced pressure
8. customThe resulting residue was purified by flash chromatography