Hydrochloric Acid → HCID 68615539, compound

HRID 1952210Notes

Reaction equation

HRID 1952210 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([C:15]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:16])[N:14]=2)[CH:11]=1)=[CH2:5])C.[ClH:24]>ClCCl>[ClH:24].[C:4]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[C:13]([C:15]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:16])[N:14]=2)[CH:11]=1)(=[O:3])[CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44136067HCID 44136067, compound

Product 1

HCID 68615539HCID 68615539, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 90 mg of 6-(1-ethoxyvinyl)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide in 2 ml of dichloromethane is stirred at 20° C. for 18 hours with 1 ml of 2N hydrochloric acid. The solid is filtered off, washed with dichloromethane and then with diisopropyl ether, and dried to give 67 mg of 6-acetyl-N-phenylimidazo[1,2-a]pyridine-2-carboxamide hydrochloride (1:1) in the form of a white solid.

Workup

  1. filtrationThe solid is filtered off
  2. washwashed with dichloromethane
  3. dry with materialwith diisopropyl ether, and dried

Sources & evidence

ORD record
ord-330eff1288ea47b292846968227bc571
Source dataset
uspto-grants-2013_03
Patent number
US08404848B2

Reaction notes

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