HCID 57702319, compound → HCID 57702317, compound

HRID 1952326Notes

Reaction equation

HRID 1952326 reaction equation
[C:1]1([CH:7]2[CH2:9][S:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>C1C=CC=CC=1>[S:8]1[CH2:9][CH:7]=[C:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]12

Participants

3

Reactant 1

HCID 57702319HCID 57702319, compound

Product 1

HCID 57702317HCID 57702317, compoundYield 35.7%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 2-cyclohex-1-enyl-thiirane (100 mg, 0.7 mmol) and Cu(tfacac)2 (78 mg, 0.21 mmol) in benzene (21 mL) were heated to 100° C. for 24 h under N2. After cooling, concentration of the solvent in vacuo afforded a residue, which was purified by column chromatography (n-pentane) to give 2,4,5,6,7,7a-Hexahydro-benzo[b]thiophene (35 mg, 35%) as a yellow oil.

Workup

  1. temperatureAfter cooling
  2. customconcentration of the solvent in vacuo afforded a residue, which
  3. customwas purified by column chromatography (n-pentane)

Sources & evidence

ORD record
ord-f8cfdeabae454566b1829ac5a5b19c0d
Source dataset
uspto-grants-2013_03
Patent number
US08404872B2

Reaction notes

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