HCID 178418361, compound → HCID 178510691, compound

HRID 1952335Notes

Reaction equation

HRID 1952335 reaction equation
[N:1]([CH2:4][C:5]1[C:13]2[C:8](=[N:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)=[N+]=[N-].[H][H]>[Pd].CCO>[NH2:1][CH2:4][C:5]1[C:13]2[C:8](=[N:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178514578HCID 178514578, compound

Product 1

HCID 178510691HCID 178510691, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 286 mg (1.64 mmol) of 1-2 and 35 mg of 10% palladium on carbon catalyst in 2 mL of absolute EtOH was hydrogentated at 1 atmosphere pressure using a hydrogen filled balloon. After approximately 2 hours, the reaction was determined to be complete by LC-MS analysis. The reaction was filtered through a Celite pad, and the filtrate concentrated in vacuo to give the title product as a pale yellow oil. MS M+1=149.

Workup

  1. filtrationThe reaction was filtered through a Celite pad
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-76a9af4014b24e5492ed553692ecc5e1
Source dataset
uspto-grants-2013_03
Patent number
US08404856B2

Reaction notes

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