HCID 59529775, compound → HCID 178509912, compound

HRID 1952342Notes

Reaction equation

HRID 1952342 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:10][C:11]2[CH:16]=[C:15]([CH2:17][CH2:18][C:19]3[C:27]4[C:22](=[N:23][CH:24]=[CH:25][CH:26]=4)[NH:21][N:20]=3)[NH:14][C:13](=[O:28])[C:12]=2Cl)[CH:9]=1)[C:5]#[N:6].ClC1C(OC2C=C(C#N)C=C(Cl)C=2)=CC(/C=C/C2C3C(=NC=CC=3)N(C(OC(C)(C)C)=O)N=2)=NC=1OC>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([O:10][C:11]2[CH:16]=[C:15]([CH2:17][CH2:18][C:19]3[C:27]4[C:22](=[N:23][CH:24]=[CH:25][CH:26]=4)[NH:21][N:20]=3)[NH:14][C:13](=[O:28])[CH:12]=2)[CH:9]=1)[C:5]#[N:6]

Participants

3

Reactant 2

HCID 59529775HCID 59529775, compoundHCID 178509913HCID 178509913, compound

Product 1

HCID 178509912HCID 178509912, compound

Procedure

In a manner identical to that described above in Step 6 for Compound 3-8, from Compound 3-7 (325 mg; 0.604 mmol) was collected Compound 3-8 and the title compound 3-9 as a by product. MS M+1=391.8: 1H NMR (DMSO-d6): 2.90 (m, 2H), 3.20 (m, 2H), 5.75 (s, 1H), 7.12 (m, 1H), 7.20 (m, 1H), 7.55 (m, 1H), 7.64 (m, 2H), 8.20 (m, 1H), 8.45 (m, 1H), 12.30 (s, 1H), 13.25 (s, 1H).

Workup

  1. customwas collected Compound 3-8

Sources & evidence

ORD record
ord-eaa07c216ccb43a987967d2c640952da
Source dataset
uspto-grants-2013_03
Patent number
US08404856B2

Reaction notes

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