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6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (300 mg, 0.974 mmol) obtained in Example 1 was dissolved in THF and 1.5 equivalents of isopropylmagnesium chloride were added thereto, followed by stirring for 1 hr at 0° C. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. Then, the resulting residue was purified by flash chromatography to obtain 155 mg of the titled compound (yield: 45.2%).

1. washThe resulting mixture washed with saturated saline
2. extractionextracted with ethyl acetate
3. customThe organic layer was separated
4. dry with materialdried over anhydrous MgSO4
5. concentrationconcentrated under a reduced pressure
6. customThen, the resulting residue was purified by flash chromatography