HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Diethoxy-1-phenyl-but-2-yn-1-ol → 4,4-Diethoxy-1-phenylbut-2-yn-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Diethoxy-1-phenyl-but-2-yn-1-ol | HCID 10889848 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4,4-Diethoxy-1-phenylbut-2-yn-1-one | HCID 12764992 | 84% |
Reaction Steps
4,4-Diethoxy-1-phenyl-but-2-yn-1-ol (9.46 g, 40.38 mmol) was dissolved in dichloromethane (200 ml) and treated with activated MnO2 (100 g) at rt for 15 h. The reaction mixture was filtered through a plug of celite and Na2SO4. The filtrated was concentrated under reduced pressure to afford the desired ketone (7.85 g, 84% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08404859B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-4af9c38d92f44d03a06dff6f6e4eb45b |
| Source note | uspto-grants-2013_03 |