Trifluoroacetic acid → HCID 68226620, compound

HRID 1952599Notes

Reaction equation

HRID 1952599 reaction equation
[CH3:1][O:2][C:3](=[O:34])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:23](=[O:33])[NH:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([OH:32])[CH:27]=2)=[CH:20][C:21]=1[Cl:22])=[O:16])[CH2:5][NH:6]C(OC(C)(C)C)=O.[C:35]([OH:41])([C:37]([F:40])([F:39])[F:38])=[O:36]>C(Cl)Cl>[F:38][C:37]([F:40])([F:39])[C:35]([OH:41])=[O:36].[CH3:1][O:2][C:3](=[O:34])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:23](=[O:33])[NH:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([OH:32])[CH:27]=2)=[CH:20][C:21]=1[Cl:22])=[O:16])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68226524HCID 68226524, compound

Product 1

HCID 68226620HCID 68226620, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-3-tert-Butoxycarbonylamino-2-{[3-chloro-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester (0.30 g, 0.59 mmol) in DCM (10 mL) was added TFA (3 mL). The mixture was stirred at room temperature 1 h and evaporated. Isolate 0.34 g of crude product which was used without further purification.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-79b905d83a8f4690bbcd21daa0587059
Source dataset
uspto-grants-2013_03
Patent number
US08404859B2

Reaction notes

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