Trifluoroacetic acid → HCID 68227405, compound

HRID 1952644Notes

Reaction equation

HRID 1952644 reaction equation
[CH3:1][O:2][C:3](=[O:35])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:23](=[O:34])[NH:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([F:32])=[C:28]([OH:33])[CH:27]=2)=[CH:20][C:21]=1[CH3:22])=[O:16])[CH2:5][NH:6]C(OC(C)(C)C)=O.[C:36]([OH:42])([C:38]([F:41])([F:40])[F:39])=[O:37]>C(Cl)Cl>[F:39][C:38]([F:41])([F:40])[C:36]([OH:42])=[O:37].[CH3:1][O:2][C:3](=[O:35])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:23](=[O:34])[NH:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([F:32])=[C:28]([OH:33])[CH:27]=2)=[CH:20][C:21]=1[CH3:22])=[O:16])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68226756HCID 68226756, compound

Product 1

HCID 68227405HCID 68227405, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-3-tert-Butoxycarbonylamino-2-{[5-(4-fluoro-3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester (0.370 g, 0.73 mmol) in DCM (10 mL) was added TFA (5 mL). The mixture was stirred at room temperature 2 h and evaporated to give crude product which was used without further purification.

Workup

  1. customevaporated
  2. customto give crude product which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-b38688e6648c4d3393a7b92df3ba24ad
Source dataset
uspto-grants-2013_03
Patent number
US08404859B2

Reaction notes

Loading…