Hydrochloric Acid → HCID 68226911, compound

HRID 1952652Notes

Reaction equation

HRID 1952652 reaction equation
[CH3:1][O:2][C:3](=[O:35])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:24](=[O:34])[NH:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([OH:33])[CH:28]=2)=[CH:20][C:21]=1[C:22]#[N:23])=[O:16])[CH2:5][NH:6]C(OC(C)(C)C)=O.[ClH:36]>O1CCOCC1>[ClH:36].[CH3:1][O:2][C:3](=[O:35])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:24](=[O:34])[NH:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([OH:33])[CH:28]=2)=[CH:20][C:21]=1[C:22]#[N:23])=[O:16])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68227112HCID 68227112, compound

Product 1

HCID 68226911HCID 68226911, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of (S)-3-tert-Butoxycarbonylamino-2-{[3-cyano-5-(3-hydroxy-benzylcarbamoyl)-thiophene-2-carbonyl]-amino}-propionic acid methyl ester (0.033 g, 0.066 mmol)) and 4.0M Hydrogen Chloride in Dioxane (5 mL) was stirred at room temperature 1 h and evaporated to give crude product which was used without further purification.

Workup

  1. customevaporated
  2. customto give crude product which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-9ad77732deb0417e90d330eb38e6366b
Source dataset
uspto-grants-2013_03
Patent number
US08404859B2

Reaction notes

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