Hydrochloric Acid → HCID 68226677, compound

HRID 1952656Notes

Reaction equation

HRID 1952656 reaction equation
[CH3:1][O:2][C:3](=[O:37])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:24](=[O:36])[NH:25][CH2:26][C:27]2[CH:35]=[CH:34][CH:33]=[C:32]3[C:28]=2[CH:29]=[N:30][NH:31]3)=[CH:20][C:21]=1[C:22]#[N:23])=[O:16])[CH2:5][NH:6]C(OC(C)(C)C)=O.[ClH:38]>O1CCOCC1.CO>[ClH:38].[CH3:1][O:2][C:3](=[O:37])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:24](=[O:36])[NH:25][CH2:26][C:27]2[CH:35]=[CH:34][CH:33]=[C:32]3[C:28]=2[CH:29]=[N:30][NH:31]3)=[CH:20][C:21]=1[C:22]#[N:23])=[O:16])[CH2:5][NH2:6]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68226502HCID 68226502, compound

Product 1

HCID 68226677HCID 68226677, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of (S)-3-tert-Butoxycarbonylamino-2-({3-cyano-5-[(1H-indazol-4-ylmethyl)-carbamoyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (0.2008 g, 0.38 mmol)) and 4.0M Hydrogen Chloride in Dioxane (10 mL) and MeOH (3 ml) was stirred at room temperature 1.5 h and evaporated to give crude product which was used without further purification.

Workup

  1. customevaporated
  2. customto give crude product which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-75509a89f2e54d6da3ad2a8063244247
Source dataset
uspto-grants-2013_03
Patent number
US08404859B2

Reaction notes

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