Pyridine → HCID 178448106, compound

HRID 1952687Notes

Reaction equation

HRID 1952687 reaction equation
[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([N:10]2[CH2:15][CH2:14][C:13](=O)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[CH3:23]CCCC>>[CH:1]([C@@H:4]1[CH2:9][CH2:8][C@H:7]([N:10]2[CH2:15][CH2:14][C:13](=[N:17][C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:23]=3)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 1049PyridineHCID 8003PentaneHCID 178448108HCID 178448108, compound

Product 1

HCID 178448106HCID 178448106, compound

Procedure

cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on (5.0 g, 23.4 mmol), pyridine (3.3 g, 35.3 mmol) and molecular sieves (20 g, 4 Å) were stirred in 100 ml pentane at room temperature for 6 days. The molecular sieves were filtered off and the solvent was evaporated. The crude product was used without any further purification for the following steps.

Workup

  1. filtrationThe molecular sieves were filtered off
  2. customthe solvent was evaporated
  3. customThe crude product was used without any further purification for the following steps

Sources & evidence

ORD record
ord-c4f88dab12164a1b9f70210202d57e01
Source dataset
uspto-grants-2000_09
Patent number
US06113527

Reaction notes

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