Lawesson's reagent → HCID 23300105, compound

HRID 1952791Notes

Reaction equation

HRID 1952791 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[C:6]([CH2:13][CH3:14])=[C:5]2[C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:30])=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[S:30])[C:6]([CH2:13][CH3:14])=[C:5]2[C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 11022747HCID 11022747, compound

Product 1

HCID 23300105HCID 23300105, compound

Procedure

150 mg (0.51 mmol) of isopropyl 6-chloro-3-ethylquinolin-2(1H)-one-4-carboxylate (Example 10) are reacted with Lawesson's reagent according to the process described in Example 5 (reaction time 5 hours at reflux temperature) and purified by means of chromatography on silica gel as indicated above (mobile phase: n-heptane/ethyl acetate=2/1).

Workup

  1. customdescribed in Example 5 (reaction time 5 hours at reflux temperature)
  2. custompurified by means of chromatography on silica gel as indicated above (mobile phase: n-heptane/ethyl acetate=2/1)

Sources & evidence

ORD record
ord-dd9ba43464c344538ac79e087e13e479
Source dataset
uspto-grants-2000_09
Patent number
US06114349

Reaction notes

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